Structure of silent transcription intervals and noise characteristics of mammalian genes Appendix
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چکیده
3 Stochastic modeling of mammalian gene expression 12 3.1 Extension of the Telegraph model: the promoter cycle . . . . . . . . . . . . . . . . . 12 3.2 Likelihood calculations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.2.1 Transition probabilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 3.2.2 Efficient likelihood computation . . . . . . . . . . . . . . . . . . . . . . . . . . 15
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Structure of silent transcription intervals and noise characteristics of mammalian genes
Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we use single allele time-lapse recordings in mouse cells to identify minimal models of promoter cycles, which inform on the number and durations of rate-limiti...
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تاریخ انتشار 2015